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Cellosaurus ABC-31 (CVCL_A6ZT)

[Text version]
Cell line name ABC-31
Accession CVCL_A6ZT
Resource Identification Initiative To cite this cell line use: ABC-31 (RRID:CVCL_A6ZT)
Comments Population: Japanese.
Characteristics: Resistant to the tyrosine kinase inhibitor osimertinib. Has activated IGF1R (PubMed=33829270).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (PubMed=33829270).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=33829270; DOI=10.1093/jjco/hyab048
Makimoto G., Ninomiya K., Kubo T., Sunami R., Kato Y., Ichihara E., Ohashi K., Rai K., Hotta K., Tabata M., Maeda Y., Kiura K.
A novel osimertinib-resistant human lung adenocarcinoma cell line harbouring mutant EGFR and activated IGF1R.
Jpn. J. Clin. Oncol. 51:956-965(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A6ZT
Encyclopedic resources Wikidata; Q107113346
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5