Cellosaurus cell line ABC-31 (CVCL

Cross-references
Cell line name	ABC-31
Accession	CVCL_A6ZT
Resource Identification Initiative	To cite this cell line use: ABC-31 (RRID:CVCL_A6ZT)
Comments	Population: Japanese. Characteristics: Resistant to the tyrosine kinase inhibitor osimertinib. Has activated IGF1R (PubMed=33829270). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (PubMed=33829270).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	63Y
Category	Cancer cell line
Publications	PubMed=33829270; DOI=10.1093/jjco/hyab048 Makimoto G., Ninomiya K., Kubo T., Sunami R., Kato Y., Ichihara E., Ohashi K., Rai K., Hotta K., Tabata M., Maeda Y., Kiura K. A novel osimertinib-resistant human lung adenocarcinoma cell line harbouring mutant EGFR and activated IGF1R. Jpn. J. Clin. Oncol. 51:956-965(2021)
Cell line databases/resources	cancercelllines; CVCL_A6ZT
Encyclopedic resources	Wikidata; Q107113346
Entry history
Entry creation	20-May-2021
Last entry update	19-Dec-2024
Version number	6