ID   ABC-31
AC   CVCL_A6ZT
DR   cancercelllines; CVCL_A6ZT
DR   Wikidata; Q107113346
RX   PubMed=33829270;
CC   Population: Japanese.
CC   Characteristics: Resistant to the tyrosine kinase inhibitor osimertinib. Has activated IGF1R (PubMed=33829270).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (PubMed=33829270).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 5
//
RX   PubMed=33829270; DOI=10.1093/jjco/hyab048;
RA   Makimoto G., Ninomiya K., Kubo T., Sunami R., Kato Y., Ichihara E.,
RA   Ohashi K., Rai K., Hotta K., Tabata M., Maeda Y., Kiura K.;
RT   "A novel osimertinib-resistant human lung adenocarcinoma cell line
RT   harbouring mutant EGFR and activated IGF1R.";
RL   Jpn. J. Clin. Oncol. 51:956-965(2021).
//