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Cellosaurus WIL2 AGr9 clone 35-1 (CVCL_A6HQ)

[Text version]
Cell line name WIL2 AGr9 clone 35-1
Synonyms AGr9 clone 35-1; AGR9 cl 35 sc 1; AGR 35sc1
Accession CVCL_A6HQ
Resource Identification Initiative To cite this cell line use: WIL2 AGr9 clone 35-1 (RRID:CVCL_A6HQ)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Children:
CVCL_A6HU (WIL2 H35.1.1)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=4527800; DOI=10.1073/pnas.71.7.2679; PMCID=PMC388531
Lever J.E., Nuki G., Seegmiller J.E.
Expression of purine overproduction in a series of 8-azaguanine-resistant diploid human lymphoblast lines.
Proc. Natl. Acad. Sci. U.S.A. 71:2679-2683(1974)

PubMed=893394; DOI=10.1016/S0021-9258(17)40020-2
Hershfield M.S., Seegmiller J.E.
Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity.
J. Biol. Chem. 252:6002-6010(1977)

PubMed=6286839; DOI=10.1084/jem.156.3.930; PMCID=PMC2186788
Chiorazzi N., Wasserman R.L., Kunkel H.G.
Use of Epstein-Barr virus-transformed B cell lines for the generation of immunoglobulin-producing human B cell hybridomas.
J. Exp. Med. 156:930-935(1982)

Cross-references
Encyclopedic resources Wikidata; Q107117455
Entry history
Entry creation20-May-2021
Last entry update29-Jun-2023
Version number4