ID   WIL2 AGr9 clone 35-1
AC   CVCL_A6HQ
SY   AGr9 clone 35-1; AGR9 cl 35 sc 1; AGR 35sc1
DR   Wikidata; Q107117455
RX   PubMed=893394;
RX   PubMed=4527800;
RX   PubMed=6286839;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
CC   Sequence variation: Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6544 ! WIL2
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 29-06-23; Version: 4
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RX   PubMed=893394; DOI=10.1016/S0021-9258(17)40020-2;
RA   Hershfield M.S., Seegmiller J.E.;
RT   "Regulation of de novo purine synthesis in human lymphoblasts. Similar
RT   rates of de novo synthesis during growth by normal cells and mutants
RT   deficient in hypoxanthine-guanine phosphoribosyltransferase
RT   activity.";
RL   J. Biol. Chem. 252:6002-6010(1977).
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RX   PubMed=4527800; DOI=10.1073/pnas.71.7.2679;
RA   Lever J.E., Nuki G., Seegmiller J.E.;
RT   "Expression of purine overproduction in a series of
RT   8-azaguanine-resistant diploid human lymphoblast lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 71:2679-2683(1974).
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RX   PubMed=6286839; DOI=10.1084/jem.156.3.930;
RA   Chiorazzi N., Wasserman R.L., Kunkel H.G.;
RT   "Use of Epstein-Barr virus-transformed B cell lines for the generation
RT   of immunoglobulin-producing human B cell hybridomas.";
RL   J. Exp. Med. 156:930-935(1982).
//