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Cellosaurus SCMC-RM2 (CVCL_A667)

[Text version]
Cell line name SCMC-RM2
Synonyms SCMC-RM-2; SCMC-R-2; SCMCRM2; Saitama Children's Medical Center-RhabdoMyosarcoma 2
Accession CVCL_A667
Secondary accession CVCL_UF93
Resource Identification Initiative To cite this cell line use: SCMC-RM2 (RRID:CVCL_A667)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 50 hours (PubMed=2323848).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: SCMC-RMZ; PubMed=19235922.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR; Note=Not found in original tumor (PubMed=23578105; CelloPub=CLPUB00599).
Disease Embryonal rhabdomyosarcoma (NCIt: C8971)
Embryonal rhabdomyosarcoma (ORDO: Orphanet_99757)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A668 (SCMC-RM2-1)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): DepMap

Markers:
AmelogeninX
CSF1PO12
D3S135815,16
D5S81811,12
D7S82011,12
D8S117914,15
D13S3179,11,12
D16S53910,11
D18S5111,13
D21S1130,33.2
FGA19,27
Penta D9
Penta E11,20,22
TH016,9
TPOX8
vWA14,18

Run an STR similarity search on this cell line
Publications

DOI=10.2198/sbk.34.289
Mizusawa H.
Operation of the JCRB cell bank and isoenzyme.
Seibutsu Butsuri Kagaku 34:289-292(1990)

PubMed=2323848; DOI=10.1002/ijc.2910450423
Hayashi Y., Sugimoto T., Horii Y., Hosoi H., Inazawa J., Kemshead J.T., Inaba T., Hanada R., Yamamoto K., Gown A.M., Sawada T.
Characterization of an embryonal rhabdomyosarcoma cell line showing amplification and over-expression of the N-myc oncogene.
Int. J. Cancer 45:705-711(1990)

CLPUB00110
Hayashi Y., Hanada R., Moriwaki K., Yamamoto K., Imaizumi S., Hirata A., Nishida T.
Establishment and characterization of cell lines derived from malignant tumors in children.
Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991)

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M., Hayashi Y.
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)

PubMed=19235922; DOI=10.1002/gcc.20655
Missiaglia E., Selfe J., Hamdi M., Williamson D., Schaaf G., Fang C., Koster J., Summersgill B.M., Messahel B., Versteeg R., Pritchard-Jones K., Kool M., Shipley J.M.
Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.
Genes Chromosomes Cancer 48:455-467(2009)

PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056
Shukla N., Ameur N., Yilmaz I., Nafa K., Lau C.-Y., Marchetti A., Borsu L., Barr F.G., Ladanyi M.
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18:748-757(2012)

PubMed=23578105; DOI=10.1111/cas.12173
Nishimura R., Takita J., Sato-Otsubo A., Kato M., Koh K., Hanada R., Tanaka Y., Kato K., Maeda D., Fukayama M., Sanada M., Hayashi Y., Ogawa S.
Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.
Cancer Sci. 104:856-864(2013)

PubMed=23882450; DOI=10.3389/fonc.2013.00183
Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G., Linardic C.M.
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front. Oncol. 3:183.1-183.12(2013)

CLPUB00599
Sugimoto T., Kuroda H., Kuwahara Y., Katsumi Y., Misawa A., Moritake H., Hosoi H.
Cellular and molecular characteristics of established childhood soft-tissue sarcoma cell lines.
J. Cancer Res. Therap. Oncol. 7:202.1-202.12(2019)

Cross-references
Cell line collections (Providers) JCRB; NIHS0044 - Discontinued
Cell line databases/resources cancercelllines; CVCL_A667
Cell_Model_Passport; SIDM01346
DepMap; ACH-001184
Encyclopedic resources Wikidata; Q54952464
Gene expression databases GEO; GSM219592
GEO; GSM1012754
Polymorphism and mutation databases Cosmic; 687965
Cosmic; 801761
Cosmic; 1037300
Cosmic; 1048113
Cosmic; 1718359
Cosmic; 2355929
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number22