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Cellosaurus U-2OSTR (CVCL_A5VC)

[Text version]
Cell line name U-2OSTR
Synonyms U-2OS(TR)
Accession CVCL_A5VC
Resource Identification Initiative To cite this cell line use: U-2OSTR (RRID:CVCL_A5VC)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224; PMCID=PMC4082476
Jacson K. Shen, Gregory M. Cote, Edwin Choy, Pei Yang, David C. Harmon, Joseph H. Schwab, Gunnlaugur Petur Nielsen, Ivan Chebib, Soldano Ferrone, Xin-Hui Wang, Yang-Yang Wang ...Show all 14 authors... , Henry J. Mankin, Francis John Hornicek, Zhen-Feng Duan; Show fewer authors
Programmed cell death ligand 1 expression in osteosarcoma.
Cancer Immunol. Res. 2:690-698(2014)

PubMed=25236161; DOI=10.1186/1471-2407-14-681; PMCID=PMC4177239
Zhen-Feng Duan, Jian-Ming Zhang, Shu-Nan Ye, Jacson K. Shen, Edwin Choy, Gregory M. Cote, David C. Harmon, Henry J. Mankin, Ying-Qi Hua, Yu Zhang, Nathanael S. Gray, Francis John Hornicek;
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Cross-references
Encyclopedic resources Wikidata; Q107117158
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6