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Cellosaurus imWilms3 (CVCL_A5SP)

[Text version]
Cell line name imWilms3
Accession CVCL_A5SP
Resource Identification Initiative To cite this cell line use: imWilms3 (RRID:CVCL_A5SP)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; None_reported; -; Zygosity=- (PubMed=33379206).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Val432Serfs*87 (c.1293_1294insA); Zygosity=Homozygous; Note=Somatic (PubMed=33379206).
Disease Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5SF (Wilms3)
Sex of cell Male
Age at sampling 11-12M
Category Conditionally immortalized cell line
Publications

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references
Encyclopedic resources Wikidata; Q107115460
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number9