Cellosaurus cell line Wilms3 (CVCL

Cellosaurus Wilms3 (CVCL_A5SF)

[Text version]

Cell line name

Wilms3

Accession

CVCL_A5SF

Resource Identification Initiative

To cite this cell line use: Wilms3 (RRID:CVCL_A5SF)

Comments

Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; None_reported; -; Zygosity=- (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Val432Serfs*87 (c.1293_1294insA); Zygosity=Homozygous; Note=Somatic (PubMed=20106868; PubMed=24619359; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_A5SP (imWilms3)

Sex of cell

Male

Age at sampling

11-12M

Category

Finite cell line

STR profile

Source(s): CLS=300414; PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D3S1358	15,16
D5S818	9
D7S820	10,11
D8S1179	10,11
D13S317	12,13
D16S539	9,11
D18S51	13,17
D21S11	29,31
FGA	22,24
Penta D	9,13
Penta E	7,10
TH01	6
TPOX	8
vWA	16,17

Publications

PubMed=20106868; DOI=10.1093/hmg/ddq042
Royer-Pokora B., Busch M.A., Beier M., Duhme C., de Torres C., Mora J., Brandt A., Royer H.-D.
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=24619359; DOI=10.1093/hmg/ddu111; PMCID=PMC4082364
Busch M.A., Schwindt H., Brandt A., Beier M., Gorldt N., Romaniuk P., Toska E., Roberts S., Royer H.-D., Royer-Pokora B.
Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation.
Hum. Mol. Genet. 23:3958-3974(2014)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Cell line collections (Providers)

CLS; 300414

Encyclopedic resources

Wikidata; Q107117469

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number