Cellosaurus cell line Wilms1-2r (CVCL

Cellosaurus Wilms1-2r (CVCL_A5SD)

Cross-references
Cell line name	Wilms1-2r
Accession	CVCL_A5SD
Resource Identification Initiative	To cite this cell line use: Wilms1-2r (RRID:CVCL_A5SD)
Comments	Population: Caucasian. Donor information: Established from the right kidney of the recurrence (2nd tumor) of the patient. Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations	Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Cys (c.134C>G); ClinVar=VCV000376242; Zygosity=Heterozygous (PubMed=33379206). Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser50Ter (c.149C>A); Zygosity=Homozygous (PubMed=33379206).
Disease	Kidney Wilms tumor (NCIt: C40407) Nephroblastoma (ORDO: Orphanet_654)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A5SC ! Wilms1-2l
Sex of cell	Female
Age at sampling	2Y
Category	Finite cell line
Publications	PubMed=17551084; DOI=10.1136/jmg.2006.047530; PMCID=PMC2740887 Duhme C., Perez N., de Torres C., Busch M.A., Mora J., Royer-Pokora B. Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation. J. Med. Genet. 44:393-396(2007) PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943 Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J. Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations. Cancers (Basel) 13:60.1-60.21(2021)
Encyclopedic resources	Wikidata; Q107117463
Entry history
Entry creation	20-May-2021
Last entry update	19-Dec-2024
Version number	6