Cellosaurus cell line Wilms1-2l (CVCL

Cellosaurus Wilms1-2l (CVCL_A5SC)

[Text version]

Cell line name

Wilms1-2l

Synonyms

Wilms1

Accession

CVCL_A5SC

Resource Identification Initiative

To cite this cell line use: Wilms1-2l (RRID:CVCL_A5SC)

Comments

Population: Caucasian.
Donor information: Established from the left kidney of the recurrence (2nd tumor) of the patient.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser50Ter (c.149C>A); Zygosity=Homozygous (PubMed=20106868; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_A5SN (imWilms1)

Originate from same individual

CVCL_A5SD ! Wilms1-2r

Sex of cell

Female

Age at sampling

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X
CSF1PO	10,12
D3S1358	14,17
D5S818	12,13
D7S820	9,14
D8S1179	12,14
D13S317	11,13
D16S539	11,14
D18S51	15,18
D21S11	30,31
FGA	22,25
Penta D	13
Penta E	5,14
TH01	9.3
TPOX	8,9
vWA	14,19

Publications

PubMed=17551084; DOI=10.1136/jmg.2006.047530; PMCID=PMC2740887
Duhme C., Perez N., de Torres C., Busch M.A., Mora J., Royer-Pokora B.
Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation.
J. Med. Genet. 44:393-396(2007)

PubMed=20106868; DOI=10.1093/hmg/ddq042
Royer-Pokora B., Busch M.A., Beier M., Duhme C., de Torres C., Mora J., Brandt A., Royer H.-D.
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Cell line collections (Providers)

CLS; 300411

Encyclopedic resources

Wikidata; Q107117461

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number