Cellosaurus cell line A549-hACE2 [Invivogen] (CVCL

Cellosaurus A549-hACE2 [Invivogen] (CVCL_A5KA)

[Text version]

Cell line name

A549-hACE2 [Invivogen]

Accession

CVCL_A5KA

Resource Identification Initiative

To cite this cell line use: A549-hACE2 [Invivogen] (RRID:CVCL_A5KA)

Comments

Group: SARS-CoV-2 research cell line.
Population: Caucasian.
Characteristics: Permissive to infection by SARS-CoV-2 and/or spike-pseudotyped lentiviral particles (InvivoGen).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0023 (A-549)
Children:

CVCL_A5KB (A549-hACE2-TMPRSS2)

Sex of cell

Male

Age at sampling

58Y