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Cellosaurus RD-SCARB2 (CVCL_A5IA)

[Text version]
Cell line name RD-SCARB2
Synonyms RDS
Accession CVCL_A5IA
Resource Identification Initiative To cite this cell line use: RD-SCARB2 (RRID:CVCL_A5IA)
Comments Population: Caucasian.
Virology: Highly susceptible to infection by enterovirus type 71 (EV71) and coxsackievirus A group type 16 (CA16) (PubMed=23919614).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1665; SCARB2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Pelvis, muscle; UBERON=UBERON_0001325.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000373003; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Embryonal rhabdomyosarcoma (NCIt: C8971)
Embryonal rhabdomyosarcoma (ORDO: Orphanet_99757)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1649 (RD)
Sex of cell Female
Age at sampling 7Y
Category Cancer cell line
Publications

PubMed=23919614; DOI=10.1186/1743-422X-10-250; PMCID=PMC3765843
Li X.-J., Fan P.-H., Jin J., Su W.-H., An D., Xu L., Sun S.-Y., Zhang Y., Meng X.-Y., Gao F., Kong W., Jiang C.-L.
Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2.
Virol. J. 10:250.1-250.11(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5IA
Encyclopedic resources Wikidata; Q107116731
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number10