Cellosaurus cell line TS603 (CVCL

Cellosaurus TS603 (CVCL_A5HW)

[Text version]

Cell line name

TS603

Accession

CVCL_A5HW

Resource Identification Initiative

To cite this cell line use: TS603 (RRID:CVCL_A5HW)

Comments

Doubling time: ~7 days (Direct_author_submission).
Miscellaneous: STR profile and doubling time from MSKCC antibody and bioresource core facility.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Sequence variations

Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (PubMed=23558169; PubMed=33504762).

Disease

Anaplastic oligodendroglioma (NCIt: C4326)
Anaplastic oligodendroglioma (ORDO: Orphanet_251630)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Category

Cancer cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X
CSF1PO	12
D1S1656	11,15
D2S441	10,11.3
D2S1338	17,25
D3S1358	16,18
D5S818	11,13
D7S820	10
D8S1179	14,15
D10S1248	13,16
D12S391	20,22
D13S317	8,9
D16S539	12
D18S51	14,16
D19S433	15.2
D21S11	29,32.2
D22S1045	16
FGA	20,21
Penta D	8,14
Penta E	16
TH01	7,9.3
TPOX	9,10
vWA	16,18

Web pages

https://www.mskcc.org/research-advantage/support/technology/tangible-material/ts603-human-brain-cancer-glioblastoma-cell-line

Publications

PubMed=23558169; DOI=10.1126/science.1236062; PMCID=PMC3985613
Rohle D., Popovici-Muller J., Palaskas N., Turcan S., Grommes C., Campos C., Tsoi J., Clark O., Oldrini B., Komisopoulou E., Kunii K., Pedraza A., Schalm S., Silverman L., Miller A., Wang F., Yang H., Chen Y., Kernytsky A., Rosenblum M.K., Liu W., Biller S.A., Su S.M., Brennan C.W., Chan T.A., Graeber T.G., Yen K.E., Mellinghoff I.K.
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Science 340:626-630(2013)

PubMed=33504762; DOI=10.1038/s41467-020-20752-6; PMCID=PMC7840755
Lita A., Pliss A., Kuzmin A., Yamasaki T., Zhang L.-M., Dowdy T., Burks C., de Val N., Celiku O., Ruiz-Rodado V., Nicoli E.-R., Kruhlak M.J., Andresson T., Das S., Yang C.-Z., Schmitt R., Herold-Mende C., Gilbert M.R., Prasad P.N., Larion M.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Nat. Commun. 12:614.1-614.16(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A5HW

Encyclopedic resources

Wikidata; Q107117130

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number