ID   TS603
AC   CVCL_A5HW
DR   cancercelllines; CVCL_A5HW
DR   Wikidata; Q107117130
RX   PubMed=23558169;
RX   PubMed=33504762;
WW   https://www.mskcc.org/research-advantage/support/technology/tangible-material/ts603-human-brain-cancer-glioblastoma-cell-line
CC   Doubling time: ~7 days (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (PubMed=23558169; PubMed=33504762).
CC   Miscellaneous: STR profile and doubling time from MSKCC antibody and bioresource core facility.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D10S1248: 13,16
ST   D12S391: 20,22
ST   D13S317: 8,9
ST   D16S539: 12
ST   D18S51: 14,16
ST   D19S433: 15.2
ST   D1S1656: 11,15
ST   D21S11: 29,32.2
ST   D22S1045: 16
ST   D2S1338: 17,25
ST   D2S441: 10,11.3
ST   D3S1358: 16,18
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 14,15
ST   FGA: 20,21
ST   Penta D: 8,14
ST   Penta E: 16
ST   TH01: 7,9.3
ST   TPOX: 9,10
ST   vWA: 16,18
DI   NCIt; C4326; Anaplastic oligodendroglioma
DI   ORDO; Orphanet_251630; Anaplastic oligodendroglioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 6
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RX   PubMed=23558169; DOI=10.1126/science.1236062; PMCID=PMC3985613;
RA   Rohle D., Popovici-Muller J., Palaskas N., Turcan S., Grommes C.,
RA   Campos C., Tsoi J., Clark O., Oldrini B., Komisopoulou E., Kunii K.,
RA   Pedraza A., Schalm S., Silverman L., Miller A., Wang F., Yang H.,
RA   Chen Y., Kernytsky A., Rosenblum M.K., Liu W., Biller S.A., Su S.M.,
RA   Brennan C.W., Chan T.A., Graeber T.G., Yen K.E., Mellinghoff I.K.;
RT   "An inhibitor of mutant IDH1 delays growth and promotes differentiation
RT   of glioma cells.";
RL   Science 340:626-630(2013).
//
RX   PubMed=33504762; DOI=10.1038/s41467-020-20752-6; PMCID=PMC7840755;
RA   Lita A., Pliss A., Kuzmin A., Yamasaki T., Zhang L.-M., Dowdy T.,
RA   Burks C., de Val N., Celiku O., Ruiz-Rodado V., Nicoli E.-R.,
RA   Kruhlak M.J., Andresson T., Das S., Yang C.-Z., Schmitt R.,
RA   Herold-Mende C., Gilbert M.R., Prasad P.N., Larion M.;
RT   "IDH1 mutations induce organelle defects via dysregulated
RT   phospholipids.";
RL   Nat. Commun. 12:614.1-614.16(2021).
//