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Cellosaurus BECK-1 (CVCL_A4BJ)

[Text version]
Cell line name BECK-1
Synonyms BECK-1732; Beck-1732
Accession CVCL_A4BJ
Resource Identification Initiative To cite this cell line use: BECK-1 (RRID:CVCL_A4BJ)
Comments Karyotypic information: 49~50,XX,+18,+i(21)(q10)x2,+mar[30] (PubMed=30862722).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Unspecified (ATCC=CRL-3384).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Unspecified (ATCC=CRL-3384).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000177778; Zygosity=Unspecified (ATCC=CRL-3384).
Disease B acute lymphoblastic leukemia (NCIt: C8644)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3384

Markers:
AmelogeninX
CSF1PO11
D5S81812
D7S82012
D13S31712
D16S53912
TH019
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=30862722; DOI=10.1158/0008-5472.CAN-18-0236; PMCID=PMC6497548
Diaz-Flores E., Comeaux E.Q., Kim K.L., Melnik E., Beckman K., Davis K.L., Wu K., Akutagawa J., Bridges O., Marino R., Wohlfeil M., Braun B.S., Mullighan C.G., Loh M.L.-C.
Bcl-2 is a therapeutic target for hypodiploid B-lineage acute lymphoblastic leukemia.
Cancer Res. 79:2339-2351(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-3384
Cell line databases/resources cancercelllines; CVCL_A4BJ
Encyclopedic resources Wikidata; Q105506478
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7