Cellosaurus cell line SK-MEL-93 DX-5 (CVCL

Cellosaurus SK-MEL-93 DX-5 (CVCL_A433)

Cross-references
Cell line name	SK-MEL-93 DX-5
Synonyms	SK-MEL-93-DX-5; SK-MEL-93 DX5; SK-MEL-93 (DX5); DX-5; DX5; SK-MEL-93(5)
Accession	CVCL_A433
Secondary accession	CVCL_U905
Resource Identification Initiative	To cite this cell line use: SK-MEL-93 DX-5 (RRID:CVCL_A433)
Comments	From: Memorial Sloan Kettering Cancer Center; New York; USA. Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=9598804). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_5651 ! SK-MEL-93 DX-1 CVCL_5652 ! SK-MEL-93 DX-2 CVCL_5650 ! SK-MEL-93 DX-3 CVCL_A432 ! SK-MEL-93 DX-4 CVCL_A434 ! SK-MEL-93 DX-6 CVCL_A435 ! SK-MEL-93 DX-B
Sex of cell	Female
Age at sampling	71Y
Category	Cancer cell line
Publications	PubMed=6976407; DOI=10.1084/jem.154.6.1764; PMCID=PMC2186539 Albino A.P., Lloyd K.O., Houghton A.N., Oettgen H.F., Old L.J. Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient Implications for the study of tumor antigens. J. Exp. Med. 154:1764-1778(1981) PubMed=2886213 Dracopoli N.C., Alhadeff B., Houghton A.N., Old L.J. Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma. Cancer Res. 47:3995-4000(1987) PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N Walker G.J., Flores J.F., Glendening J.M., Lin A.H.-T., Markl I.D.C., Fountain J.W. Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer 22:157-163(1998)
Encyclopedic resources	Wikidata; Q54954345
Polymorphism and mutation databases	Cosmic; 721819 Cosmic; 926004 Cosmic; 933123
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	14