ID   SK-MEL-93 DX-5
AC   CVCL_A433
AS   CVCL_U905
SY   SK-MEL-93-DX-5; SK-MEL-93 DX5; SK-MEL-93 (DX5); DX-5; DX5; SK-MEL-93(5)
DR   Cosmic; 721819
DR   Cosmic; 926004
DR   Cosmic; 933123
DR   Wikidata; Q54954345
RX   PubMed=2886213;
RX   PubMed=6976407;
RX   PubMed=9598804;
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=9598804).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=9598804).
CC   Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5651 ! SK-MEL-93 DX-1
OI   CVCL_5652 ! SK-MEL-93 DX-2
OI   CVCL_5650 ! SK-MEL-93 DX-3
OI   CVCL_A432 ! SK-MEL-93 DX-4
OI   CVCL_A434 ! SK-MEL-93 DX-6
OI   CVCL_A435 ! SK-MEL-93 DX-B
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 14
//
RX   PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N;
RA   Walker, Graeme J.
RA   Flores, Jose F.
RA   Glendening, J. Michael
RA   Lin, Amy Hsiu-Ti
RA   Markl, Isabel D.C.
RA   Fountain, Jane W.
RT   "Virtually 100% of melanoma cell lines harbor alterations at the DNA
RT   level within CDKN2A, CDKN2B, or one of their downstream targets.";
RL   Genes Chromosomes Cancer 22:157-163(1998).
//
RX   PubMed=2886213;
RA   Dracopoli, Nicholas C.
RA   Alhadeff, Becky
RA   Houghton, Alan N.
RA   Old, Lloyd John
RT   "Loss of heterozygosity at autosomal and X-linked loci during tumor
RT   progression in a patient with melanoma.";
RL   Cancer Res. 47:3995-4000(1987).
//
RX   PubMed=6976407; DOI=10.1084/jem.154.6.1764; PMCID=PMC2186539;
RA   Albino, Anthony P.
RA   Lloyd, Kenneth Oliver
RA   Houghton, Alan N.
RA   Oettgen, Herbert Friedrich
RA   Old, Lloyd John
RT   "Heterogeneity in surface antigen and glycoprotein expression of cell
RT   lines derived from different melanoma metastases of the same patient.
RT   Implications for the study of tumor antigens.";
RL   J. Exp. Med. 154:1764-1778(1981).
//