Cellosaurus cell line HCE-6 (CVCL

Cellosaurus HCE-6 (CVCL_A357)

Cross-references
Cell line name	HCE-6
Accession	CVCL_A357
Resource Identification Initiative	To cite this cell line use: HCE-6 (RRID:CVCL_A357)
Comments	Doubling time: 27 hours (PubMed=2415247). Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ser (c.832C>T); ClinVar=VCV000376642; Zygosity=Unspecified (PubMed=2263646).
Disease	Esophageal squamous cell carcinoma (NCIt: C4024) Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	42Y
Category	Cancer cell line
Publications	PubMed=2415247 Banks-Schlegel S.P., Quintero J. Growth and differentiation of human esophageal carcinoma cell lines. Cancer Res. 46:250-258(1986) PubMed=2420787; DOI=10.1016/S0021-9258(17)38506-X Banks-Schlegel S.P., Quintero J. Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors. J. Biol. Chem. 261:4359-4362(1986) PubMed=2263646; DOI=10.1073/pnas.87.24.9958; PMCID=PMC55293 Hollstein M.C., Metcalf R.A., Welsh J.A., Montesano R., Harris C.C. Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl. Acad. Sci. U.S.A. 87:9958-9961(1990) PubMed=2302677; DOI=10.1016/0165-4608(90)90073-j Whang-Peng J., Banks-Schlegel S.P., Lee E.C. Cytogenetic studies of esophageal carcinoma cell lines. Cancer Genet. Cytogenet. 45:101-120(1990)
Cell line databases/resources	cancercelllines; CVCL_A357
Anatomy/cell type resources	BTO; BTO_0005573
Encyclopedic resources	Wikidata; Q54881851
Polymorphism and mutation databases	Cosmic; 1394514 IARC_TP53; 259
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	13