Cellosaurus logo
expasy logo

Cellosaurus TS-2 (CVCL_A323)

[Text version]
Cell line name TS-2
Accession CVCL_A323
Resource Identification Initiative To cite this cell line use: TS-2 (RRID:CVCL_A323)
Comments Population: Japanese.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2683; DAZAP1 + HGNC; HGNC:6997; MEF2D; Name(s)=MEF2D-DAZAP1; Note=MEF2D exon 6 fused to DAZAP1 exon 7 and DAZAP1 exon 6 to MEF2D exon 7, both in frame (PubMed=15182431; PubMed=15744350; PubMed=32504922).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3Y
Category Cancer cell line
Publications

PubMed=9494609; DOI=10.1016/S0165-4608(97)00260-4
Yoshinari M., Imaizumi M., Eguchi M., Ogasawara M., Saito T., Suzuki H., Koizumi Y., Cui Y., Sato A., Saisho T., Ichinohasama R., Matsubara Y., Kamada N., Iinuma K.
Establishment of a novel cell line (TS-2) of pre-B acute lymphoblastic leukemia with a t(1;19) not involving the E2A gene.
Cancer Genet. Cytogenet. 101:95-102(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15182431; DOI=10.1111/j.1349-7006.2004.tb03240.x; PMCID=PMC11159863
Yuki Y., Imoto I., Imaizumi M., Hibi S., Kaneko Y., Amagasa T., Inazawa J.
Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).
Cancer Sci. 95:503-507(2004)

PubMed=15744350; DOI=10.1038/sj.leu.2403684
Prima V., Gore L., Caires A., Boomer T., Yoshinari M., Imaizumi M., Varella-Garcia M., Hunger S.P.
Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.
Leukemia 19:806-813(2005)

PubMed=32504922; DOI=10.1016/j.biopha.2020.110330
Tange N., Hayakawa F., Yasuda T., Odaira K., Yamamoto H., Hirano D., Sakai T., Terakura S., Tsuzuki S., Kiyoi H.
Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.
Biomed. Pharmacother. 128:110330-110330(2020)

Cross-references
Encyclopedic resources Wikidata; Q54973052
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number14