ID   TS-2
AC   CVCL_A323
DR   Wikidata; Q54973052
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9494609;
RX   PubMed=15182431;
RX   PubMed=15744350;
RX   PubMed=32504922;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2683; DAZAP1 + HGNC; HGNC:6997; MEF2D; Name(s)=MEF2D-DAZAP1; Note=MEF2D exon 6 fused to DAZAP1 exon 7 and DAZAP1 exon 6 to MEF2D exon 7, both in frame (PubMed=15182431; PubMed=15744350; PubMed=32504922).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   3Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 14
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9494609; DOI=10.1016/S0165-4608(97)00260-4;
RA   Yoshinari M., Imaizumi M., Eguchi M., Ogasawara M., Saito T.,
RA   Suzuki H., Koizumi Y., Cui Y., Sato A., Saisho T., Ichinohasama R.,
RA   Matsubara Y., Kamada N., Iinuma K.;
RT   "Establishment of a novel cell line (TS-2) of pre-B acute
RT   lymphoblastic leukemia with a t(1;19) not involving the E2A gene.";
RL   Cancer Genet. Cytogenet. 101:95-102(1998).
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RX   PubMed=15182431; DOI=10.1111/j.1349-7006.2004.tb03240.x; PMCID=PMC11159863;
RA   Yuki Y., Imoto I., Imaizumi M., Hibi S., Kaneko Y., Amagasa T.,
RA   Inazawa J.;
RT   "Identification of a novel fusion gene in a pre-B acute lymphoblastic
RT   leukemia with t(1;19)(q23;p13).";
RL   Cancer Sci. 95:503-507(2004).
//
RX   PubMed=15744350; DOI=10.1038/sj.leu.2403684;
RA   Prima V., Gore L., Caires A., Boomer T., Yoshinari M., Imaizumi M.,
RA   Varella-Garcia M., Hunger S.P.;
RT   "Cloning and functional characterization of MEF2D/DAZAP1 and
RT   DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3)
RT   in acute lymphoblastic leukemia.";
RL   Leukemia 19:806-813(2005).
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RX   PubMed=32504922; DOI=10.1016/j.biopha.2020.110330;
RA   Tange N., Hayakawa F., Yasuda T., Odaira K., Yamamoto H., Hirano D.,
RA   Sakai T., Terakura S., Tsuzuki S., Kiyoi H.;
RT   "Staurosporine and venetoclax induce the caspase-dependent proteolysis
RT   of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL
RT   cells.";
RL   Biomed. Pharmacother. 128:110330-110330(2020).
//