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Cellosaurus A-253 clone D3 (CVCL_A2ES)

[Text version]
Cell line name A-253 clone D3
Synonyms D3
Accession CVCL_A2ES
Resource Identification Initiative To cite this cell line use: A-253 clone D3 (RRID:CVCL_A2ES)
Comments Population: Caucasian.
Characteristics: Clone of acinar origin (PubMed=32842479).
Derived from site: In situ; Salivary gland, submandibular gland; UBERON=UBERON_0001736.
Cell type: Salivary gland acinar cell; CL=CL_0002623.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala17fs*5 (c.49_61delGCCACGGCCGCGG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7133; KMT2D; Simple; p.Gly3092Ter (c.9274G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu152Pro (c.455T>C); ClinVar=VCV000536551; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu180fs*67 (c.539delA); Zygosity=Homozygous (from parent cell line).
Disease Submandibular gland squamous cell carcinoma (NCIt: C5943)
Squamous cell carcinoma of salivary glands (ORDO: Orphanet_500481)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1060 (A-253)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=32842479; DOI=10.3390/biomedicines8090302; PMCID=PMC7555419
Lin G.C., Smajlhodzic-Deljo M., Bandian A.-M., Friedl H.-P., Leitgeb T., Oerter S., Stadler K., Giese U., Peham J.R., Bingle L., Neuhaus W.
An in vitro barrier model of the human submandibular salivary gland epithelium based on a single cell clone of cell line HTB-41: establishment and application for biomarker transport studies.
Biomedicines 8:302.1-302.16(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2ES
Encyclopedic resources Wikidata; Q105506014
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number7