ID   A-253 clone D3
AC   CVCL_A2ES
SY   D3
DR   cancercelllines; CVCL_A2ES
DR   Wikidata; Q105506014
RX   PubMed=32842479;
CC   Population: Caucasian.
CC   Characteristics: Clone of acinar origin (PubMed=32842479).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala17fs*5 (c.49_61delGCCACGGCCGCGG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7133; KMT2D; Simple; p.Gly3092Ter (c.9274G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Leu152Pro (c.455T>C); ClinVar=VCV000536551; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu180fs*67 (c.539delA); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Salivary gland, submandibular gland; UBERON=UBERON_0001736.
CC   Cell type: Salivary gland acinar cell; CL=CL_0002623.
DI   NCIt; C5943; Submandibular gland squamous cell carcinoma
DI   ORDO; Orphanet_500481; Squamous cell carcinoma of salivary glands
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1060 ! A-253
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 05-10-23; Version: 7
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RX   PubMed=32842479; DOI=10.3390/biomedicines8090302; PMCID=PMC7555419;
RA   Lin G.C., Smajlhodzic-Deljo M., Bandian A.-M., Friedl H.-P., Leitgeb T.,
RA   Oerter S., Stadler K., Giese U., Peham J.R., Bingle L., Neuhaus W.;
RT   "An in vitro barrier model of the human submandibular salivary gland
RT   epithelium based on a single cell clone of cell line HTB-41:
RT   establishment and application for biomarker transport studies.";
RL   Biomedicines 8:302.1-302.16(2020).
//