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Cellosaurus OXCO-2 R3 Cetux (CVCL_A2CJ)

[Text version]
Cell line name OXCO-2 R3 Cetux
Accession CVCL_A2CJ
Resource Identification Initiative To cite this cell line use: OXCO-2 R3 Cetux (RRID:CVCL_A2CJ)
Comments Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Ser464Leu (c.1391C>T); Zygosity=Heterozygous; Note=Acquired during resistance selection process (PubMed=25623215).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2H53 (OX-CO-2)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Encyclopedic resources Wikidata; Q105510530
Polymorphism and mutation databases Cosmic; 2841378
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number5