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Cellosaurus LB21 (CVCL_A1YE)

[Text version]
Cell line name LB21
Synonyms PARK8-LB21
Accession CVCL_A1YE
Resource Identification Initiative To cite this cell line use: LB21 (RRID:CVCL_A1YE)
Comments Population: Japanese.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
Disease Parkinson disease 8, autosomal dominant (NCIt: C198605)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A1YD ! LB16
Sex of cell Female
Age at sampling 78Y
Category Induced pluripotent stem cell
Publications

PubMed=26056228; DOI=10.1093/hmg/ddv212
Ohta E., Nihira T., Uchino A., Imaizumi Y., Okada Y., Akamatsu W., Takahashi K., Hayakawa H., Nagai M., Ohyama M., Ryo M., Ogino M., Murayama S., Takashima A., Nishiyama K., Mizuno Y., Mochizuki H., Obata F., Okano H.
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway.
Hum. Mol. Genet. 24:4879-4900(2015)

Cross-references
Cell line databases/resources SKIP; SKIP000994
Encyclopedic resources Wikidata; Q105509854
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6