Cellosaurus cell line LB16 (CVCL

Cross-references
Cell line name	LB16
Synonyms	PARK8-LB16
Accession	CVCL_A1YD
Resource Identification Initiative	To cite this cell line use: LB16 (RRID:CVCL_A1YD)
Comments	Population: Japanese. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:18618; LRRK2; Simple; p.Ile2020Thr (c.6059C>T); ClinVar=VCV000001941; Zygosity=Heterozygous (PubMed=26056228).
Disease	Parkinson disease 8, autosomal dominant (NCIt: C198605) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A1YE ! LB21
Sex of cell	Female
Age at sampling	78Y
Category	Induced pluripotent stem cell
Publications	PubMed=26056228; DOI=10.1093/hmg/ddv212 Ohta E., Nihira T., Uchino A., Imaizumi Y., Okada Y., Akamatsu W., Takahashi K., Hayakawa H., Nagai M., Ohyama M., Ryo M., Ogino M., Murayama S., Takashima A., Nishiyama K., Mizuno Y., Mochizuki H., Obata F., Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. Hum. Mol. Genet. 24:4879-4900(2015)
Cell line databases/resources	SKIP; SKIP000993
Encyclopedic resources	Wikidata; Q105509848
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	6