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Cellosaurus COLO 38R (CVCL_A1FC)

[Text version]
Cell line name COLO 38R
Synonyms Colo38-R; Colo38R
Accession CVCL_A1FC
Resource Identification Initiative To cite this cell line use: COLO 38R (RRID:CVCL_A1FC)
Comments Problematic cell line: Contaminated. Parent cell line (COLO 38) has been shown to be a M14 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24732172).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3934 (COLO 38)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=24732172; DOI=10.18632/oncotarget.1878; PMCID=PMC4039118
Sabbatino F., Wang Y.-Y., Wang X.-H., Flaherty K.T., Yu L., Pepin D., Scognamiglio G., Pepe S., Kirkwood J.M., Cooper Z.A., Frederick D.T., Wargo J.A., Ferrone S., Ferrone C.R.
PDGFRalpha up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Oncotarget 5:1926-1941(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1FC
Encyclopedic resources Wikidata; Q102113700
Polymorphism and mutation databases Cosmic; 2757119
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8