ID   COLO 38R
AC   CVCL_A1FC
SY   Colo38-R; Colo38R
DR   cancercelllines; CVCL_A1FC
DR   Cosmic; 2757119
DR   Wikidata; Q102113700
RX   PubMed=24732172;
CC   Problematic cell line: Contaminated. Parent cell line (COLO 38) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24732172).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3934 ! COLO 38
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 19-12-24; Version: 8
//
RX   PubMed=24732172; DOI=10.18632/oncotarget.1878; PMCID=PMC4039118;
RA   Sabbatino, Francesco
RA   Wang, Yang-Yang
RA   Wang, Xin-Hui
RA   Flaherty, Keith Thomas
RA   Yu, Ling
RA   Pepin, David
RA   Scognamiglio, Giosue
RA   Pepe, Stefano
RA   Kirkwood, John Munn
RA   Cooper, Zachary A.
RA   Frederick, Dennie T.
RA   Wargo, Jennifer A.
RA   Ferrone, Soldano
RA   Ferrone, Cristina Rosa
RT   "PDGFRalpha up-regulation mediated by sonic hedgehog pathway
RT   activation leads to BRAF inhibitor resistance in melanoma cells with
RT   BRAF mutation.";
RL   Oncotarget 5:1926-1941(2014).
//