ID   COLO 38R
AC   CVCL_A1FC
SY   Colo38-R; Colo38R
DR   cancercelllines; CVCL_A1FC
DR   Cosmic; 2757119
DR   Wikidata; Q102113700
RX   PubMed=24732172;
CC   Problematic cell line: Contaminated. Parent cell line (COLO 38) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24732172).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3934 ! COLO 38
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 05-10-23; Version: 7
//
RX   PubMed=24732172; DOI=10.18632/oncotarget.1878;
RA   Sabbatino F., Wang Y.-Y., Wang X.-H., Flaherty K.T., Yu L., Pepin D.,
RA   Scognamiglio G., Pepe S., Kirkwood J.M., Cooper Z.A., Frederick D.T.,
RA   Wargo J.A., Ferrone S., Ferrone C.R.;
RT   "PDGFRalpha up-regulation mediated by sonic hedgehog pathway
RT   activation leads to BRAF inhibitor resistance in melanoma cells with
RT   BRAF mutation.";
RL   Oncotarget 5:1926-1941(2014).
//