Cellosaurus cell line MDA-T273 (CVCL

Cellosaurus MDA-T273 (CVCL_A1CV)

[Text version]

Cell line name

MDA-T273

Accession

CVCL_A1CV

Resource Identification Initiative

To cite this cell line use: MDA-T273 (RRID:CVCL_A1CV)

Comments

Doubling time: 33.9 hours (PubMed=34147031).
Miscellaneous: Age of donor from personal communication of Henderson, Ying C.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Homozygous (PubMed=34147031).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=34147031).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=34147031).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

51Y

Category

Cancer cell line

STR profile

Source(s): PubMed=34147031

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	12
D7S820	10,11
D13S317	9
D16S539	11
TH01	7,9
TPOX	8,11
vWA	14

Publications

PubMed=34147031; DOI=10.1210/clinem/dgab453; PMCID=PMC8530744
Maniakas A., Henderson Y.C., Hei H., Peng S.-H., Chen Y.-Y., Jiang Y.-J., Ji S.-X., Cardenas M., Chiu Y.-L., Bell D., Williams M.D., Hofmann M.-C., Scherer S.E., Wheeler D.A., Busaidy N.L., Dadu R., Wang J.R., Cabanillas M.E., Zafereo M., Johnson F.M., Lai S.Y.
Novel anaplastic thyroid cancer PDXs and cell lines: expanding preclinical models of genetic diversity.
J. Clin. Endocrinol. Metab. 106:e4652-e4665(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A1CV

Encyclopedic resources

Wikidata; Q102114528

Entry history

Entry creation

29-Oct-2020

Last entry update

19-Dec-2024

Version number