ID   MDA-T273
AC   CVCL_A1CV
DR   cancercelllines; CVCL_A1CV
DR   Wikidata; Q102114528
RX   PubMed=34147031;
CC   Doubling time: 33.9 hours (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Homozygous (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=34147031).
CC   Miscellaneous: Age of donor from personal communication of Henderson, Ying C.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=34147031
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 10,11
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 19-12-24; Version: 9
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RX   PubMed=34147031; DOI=10.1210/clinem/dgab453; PMCID=PMC8530744;
RA   Maniakas A., Henderson Y.C., Hei H., Peng S.-H., Chen Y.-Y.,
RA   Jiang Y.-J., Ji S.-X., Cardenas M., Chiu Y.-L., Bell D., Williams M.D.,
RA   Hofmann M.-C., Scherer S.E., Wheeler D.A., Busaidy N.L., Dadu R.,
RA   Wang J.R., Cabanillas M.E., Zafereo M., Johnson F.M., Lai S.Y.;
RT   "Novel anaplastic thyroid cancer PDXs and cell lines: expanding
RT   preclinical models of genetic diversity.";
RL   J. Clin. Endocrinol. Metab. 106:e4652-e4665(2021).
//