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Cellosaurus MAgEC 11.5 (CVCL_A1AY)

[Text version]
Cell line name MAgEC 11.5
Synonyms Mouse Aorta gonad mesonephros Endothelial Cells 11.5 dpc
Accession CVCL_A1AY
Resource Identification Initiative To cite this cell line use: MAgEC 11.5 (RRID:CVCL_A1AY)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-4223.
Characteristics: Displays progenitor endothelial characteristics. Is more differentiated than MAgEC 10.5 (Cellosaurus=CVCL_A1AY) and displays faster angiogenesis in vitro, different response to hypoxia and chemokines (PubMed=26577811).
Doubling time: ~24 hours (PubMed=26577811).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Embryonic aorta-gonad-mesonephros; UBERON=UBERON_0003105.
Cell type: Endothelial cell of aorta; CL=CL_0002544.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: FVB.
Sex of cell Sex unspecified
Age at sampling 10-11FD
Category Transformed cell line
Publications

PubMed=26577811; DOI=10.1016/j.canlet.2015.11.008
Collet G., Szade K., Nowak W.N., Klimkiewicz K., El Hafny-Rahbi B., Szczepanek K., Sugiyama D., Weglarczyk K., Foucault-Collet A., Guichard A., Mazan A., Nadim M., Fasani F., Lamerant-Fayel N., Grillon C., Petoud S., Beloeil J.-C., Jozkowicz A., Dulak J., Kieda C.
Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia.
Cancer Lett. 370:345-357(2016)

Patent=US9631178
Kieda C., Grillon C., Lamerant-Fayel N., Paprocka M., Krawczenko A., Dus D.
Human and murine stem-cell lines: models of endothelial cell precursors.
Patent number US9631178, 25-Apr-2017

Cross-references
Encyclopedic resources Wikidata; Q102114496
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7