Cellosaurus cell line MDA-MB-231br (CVCL

Cellosaurus MDA-MB-231br (CVCL_A0YY)

[Text version]

Cell line name

MDA-MB-231br

Synonyms

MDA-231BR

Accession

CVCL_A0YY

Resource Identification Initiative

To cite this cell line use: MDA-MB-231br (RRID:CVCL_A0YY)

Comments

Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).

Disease

Breast adenocarcinoma (NCIt: C5214)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0062 (MDA-MB-231)
Children:

CVCL_B0A0 (MDA-MB-231br/eGFP)

Sex of cell

Female

Age at sampling

51Y