| Cell line name |
MDA-MB-231br |
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| Synonyms |
MDA-231BR |
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| Accession |
CVCL_A0YY |
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| Resource Identification Initiative |
To cite this cell line use: MDA-MB-231br (RRID:CVCL_A0YY) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11499871; DOI=10.1359/jbmr.2001.16.8.1486
Yoneda T., Williams P.J., Hiraga T., Niewolna M., Nishimura R.
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro.
J. Bone Miner. Res. 16:1486-1495(2001) PubMed=33264355; DOI=10.1371/journal.pone.0243156; PMCID=PMC7710086
De Meulenaere V., Descamps B., De Wever O., Vanhove C., Deblaere K.
In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain a clinically relevant rat model for triple negative breast cancer brain metastasis.
PLoS ONE 15:E0243156-E0243156(2020) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A0YY
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| Encyclopedic resources |
Wikidata; Q108820878
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| Entry history |
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| Entry creation | 23-Sep-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 7 |
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