ID   MDA-MB-231br
AC   CVCL_A0YY
SY   MDA-231BR
DR   cancercelllines; CVCL_A0YY
DR   Wikidata; Q108820878
RX   PubMed=11499871;
RX   PubMed=33264355;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 05-10-23; Version: 6
//
RX   PubMed=11499871; DOI=10.1359/jbmr.2001.16.8.1486;
RA   Yoneda T., Williams P.J., Hiraga T., Niewolna M., Nishimura R.;
RT   "A bone-seeking clone exhibits different biological properties from
RT   the MDA-MB-231 parental human breast cancer cells and a brain-seeking
RT   clone in vivo and in vitro.";
RL   J. Bone Miner. Res. 16:1486-1495(2001).
//
RX   PubMed=33264355; DOI=10.1371/journal.pone.0243156;
RA   De Meulenaere V., Descamps B., De Wever O., Vanhove C., Deblaere K.;
RT   "In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain
RT   a clinically relevant rat model for triple negative breast cancer
RT   brain metastasis.";
RL   PLoS ONE 15:E0243156-E0243156(2020).
//