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Cellosaurus N2A Psen1/Psen2 dKO (CVCL_A0TK)

[Text version]
Cell line name N2A Psen1/Psen2 dKO
Synonyms N2A Psen1/Psen2 double knockout; N2A-PS1/2KO-8/71
Accession CVCL_A0TK
Resource Identification Initiative To cite this cell line use: N2A Psen1/Psen2 dKO (RRID:CVCL_A0TK)
Comments Knockout cell: Method=CRISPR/Cas9; MGI; MGI:1202717; Psen1.
Knockout cell: Method=CRISPR/Cas9; MGI; MGI:109284; Psen2.
Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
Cell type: Neural crest derived neuroblast; CL=CL_0002676.
Disease Mouse neuroblastoma (NCIt: C21993)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: A/J.
Hierarchy Parent: CVCL_0470 (Neuro-2a)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Millipore=SCC297

Markers:
Mouse STR 1-111
Mouse STR 1-217,18
Mouse STR 2-116
Mouse STR 3-213,14
Mouse STR 4-221.3,22.3
Mouse STR 5-515,17
Mouse STR 6-418,20
Mouse STR 6-712
Mouse STR 7-125.2
Mouse STR 8-116,17
Mouse STR 11-215
Mouse STR 12-116
Mouse STR 13-116.2,17.2
Mouse STR 15-321.3,22.3,23.3,24.3
Mouse STR 17-216,17
Mouse STR 18-322
Mouse STR 19-212
Mouse STR X-126,27

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Publications

PubMed=32032730; DOI=10.1016/j.nbd.2020.104785; PMCID=PMC7515654
Pimenova A.A., Goate A.M.
Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations.
Neurobiol. Dis. 138:104785.1-104785.11(2020)

Cross-references
Cell line collections (Providers) Millipore; SCC297
Encyclopedic resources Wikidata; Q108821007
Entry history
Entry creation23-Sep-2021
Last entry update02-May-2024
Version number6