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Cellosaurus HSB.2-A7-D9 (CVCL_A0DS)

[Text version]
Cell line name HSB.2-A7-D9
Accession CVCL_A0DS
Resource Identification Initiative To cite this cell line use: HSB.2-A7-D9 (RRID:CVCL_A0DS)
Comments Population: Caucasian.
Characteristics: Produces high level of IL2 in response to IL1.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; 10879; STIL + HGNC; 11556; TAL1; Name(s)=STIL-TAL1, SIL-TAL1, SIL-SCL (from parent cell line).
  • Mutation; HGNC; 3430; ERBB2; Simple; p.Pro1175Arg (c.3524C>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr226His (c.676T>C); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 3690; FGFR3; Simple; p.Arg621His (c.1862G>A); ClinVar=VCV000016355; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Thr454Ile (c.1361C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Gln455Lys (c.1363C>A); Zygosity=Unspecified (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1859 (CCRF-HSB-2)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=3871456; DOI=10.4049/jimmunol.134.3.1682
Kasahara T., Mukaida N., Hatake K., Motoyoshi K., Kawai T., Shiori-Nakano K.
Interleukin 1 (IL 1)-dependent lymphokine production by human leukemic T cell line HSB.2 subclones.
J. Immunol. 134:1682-1689(1985)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0DS
Encyclopedic resources Wikidata; Q108820503
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number6