| Cell line name |
HSB.2-A7-D2 |
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| Accession |
CVCL_A0DR |
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| Resource Identification Initiative |
To cite this cell line use: HSB.2-A7-D2 (RRID:CVCL_A0DR) |
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| Comments |
Population: Caucasian.
Characteristics: Produces high level of IL2 in response to IL1.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:10879; STIL + HGNC; HGNC:11556; TAL1; Name(s)=STIL-TAL1, SIL-TAL1, SIL-SCL (from parent cell line).
- Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1175Arg (c.3524C>G); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr226His (c.676T>C); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Arg621His (c.1862G>A); ClinVar=VCV000016355; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Thr454Ile (c.1361C>T); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Gln455Lys (c.1363C>A); Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1859 (CCRF-HSB-2) |
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| Sex of cell |
Male |
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| Age at sampling |
11Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=3871456; DOI=10.4049/jimmunol.134.3.1682
Kasahara T., Mukaida N., Hatake K., Motoyoshi K., Kawai T., Shiori-Nakano K.
Interleukin 1 (IL 1)-dependent lymphokine production by human leukemic T cell line HSB.2 subclones.
J. Immunol. 134:1682-1689(1985) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A0DR
|
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| Encyclopedic resources |
Wikidata; Q108820502
|
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| Entry history |
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| Entry creation | 23-Sep-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 7 |
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