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Cellosaurus VCaP-CR (CVCL_A0BX)

[Text version]
Cell line name VCaP-CR
Accession CVCL_A0BX
Resource Identification Initiative To cite this cell line use: VCaP-CR (RRID:CVCL_A0BX)
Comments Population: Caucasian.
Characteristics: Derived after a passage of the parent cell line in castrated nude mice.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Doubling time: ~60 hours (PubMed=34402095).
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=34402095; DOI=10.1002/pros.24210
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J.L., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0BX
Encyclopedic resources Wikidata; Q108821488
Gene expression databases GEO; GSM5402197
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number7