Cellosaurus cell line UMB-SCC-745 (CVCL

Cellosaurus UMB-SCC-745 (CVCL_A093)

Cross-references
Cell line name	UMB-SCC-745
Synonyms	University of Marburg-Squamous Cell Carcinoma-745
Accession	CVCL_A093
Resource Identification Initiative	To cite this cell line use: UMB-SCC-745 (RRID:CVCL_A093)
Comments	Caution: Indicated as originating from tonsil in PubMed=16035614 and from orapharynx in PubMed=16203773 and PubMed=19414362.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu349Ter (c.1045G>T); ClinVar=VCV000634695; Zygosity=Unspecified (PubMed=16203773).
Disease	Oropharyngeal squamous cell carcinoma (NCIt: C8181) Squamous cell carcinoma of the oropharynx (ORDO: Orphanet_500478)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	48Y
Category	Cancer cell line
Publications	PubMed=16035614; DOI=10.1007/s10585-004-6918-5 Mandic R., Ludwig T., Oberleithner H., Werner J.A. Evaluation of head and neck squamous cell carcinoma invasiveness by the electrical resistance breakdown assay. Clin. Exp. Metastasis 21:699-704(2004) PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378 Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L., Carey T.E., Grenman R., Dunne A.A., Werner J.A. Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53. Clin. Cancer Res. 11:6845-6852(2005) PubMed=19414362 Mandic R., Rodgarkia-Dara C.J., Krohn V., Wiegand S., Grenman R., Werner J.A. Cisplatin resistance of the HNSCC cell line UT-SCC-26A can be overcome by stimulation of the EGF-receptor. Anticancer Res. 29:1181-1187(2009)
Cell line databases/resources	cancercelllines; CVCL_A093
Encyclopedic resources	Wikidata; Q54991067
Polymorphism and mutation databases	Cosmic; 1483461 IARC_TP53; 23609
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	13