ID   UMB-SCC-745
AC   CVCL_A093
SY   University of Marburg-Squamous Cell Carcinoma-745
DR   cancercelllines; CVCL_A093
DR   Cosmic; 1483461
DR   IARC_TP53; 23609
DR   Wikidata; Q54991067
RX   PubMed=16035614;
RX   PubMed=16203773;
RX   PubMed=19414362;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu349Ter (c.1045G>T); ClinVar=VCV000634695; Zygosity=Unspecified (PubMed=16203773).
CC   Caution: Indicated as originating from tonsil in PubMed=16035614 and from orapharynx in PubMed=16203773 and PubMed=19414362.
DI   NCIt; C8181; Oropharyngeal squamous cell carcinoma
DI   ORDO; Orphanet_500478; Squamous cell carcinoma of the oropharynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 13
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RX   PubMed=16035614; DOI=10.1007/s10585-004-6918-5;
RA   Mandic R., Ludwig T., Oberleithner H., Werner J.A.;
RT   "Evaluation of head and neck squamous cell carcinoma invasiveness by
RT   the electrical resistance breakdown assay.";
RL   Clin. Exp. Metastasis 21:699-704(2004).
//
RX   PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378;
RA   Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L.,
RA   Carey T.E., Grenman R., Dunne A.A., Werner J.A.;
RT   "Reduced cisplatin sensitivity of head and neck squamous cell
RT   carcinoma cell lines correlates with mutations affecting the
RT   COOH-terminal nuclear localization signal of p53.";
RL   Clin. Cancer Res. 11:6845-6852(2005).
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RX   PubMed=19414362;
RA   Mandic R., Rodgarkia-Dara C.J., Krohn V., Wiegand S., Grenman R.,
RA   Werner J.A.;
RT   "Cisplatin resistance of the HNSCC cell line UT-SCC-26A can be
RT   overcome by stimulation of the EGF-receptor.";
RL   Anticancer Res. 29:1181-1187(2009).
//