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Cellosaurus YCUB-5 (CVCL_A085)

[Text version]
Cell line name YCUB-5
Synonyms YCUB5; YcuB5; Yokohama City University BCP-ALL-5
Accession CVCL_A085
Resource Identification Initiative To cite this cell line use: YCUB-5 (RRID:CVCL_A085)
Comments Population: Japanese.
Doubling time: ~72 hours (DSMZ=ACC-964).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:14281; CRLF2 + HGNC; HGNC:15524; P2RY8; Name(s)=P2RY8-CRLF2; Note=P2RY8 exon 1 fused to CRLF2 exon 1 (PubMed=29786757).
  • Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Arg683Ile (c.2048G>T); Zygosity=Unspecified (PubMed=29786757).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=29786757).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A086 ! YCUB-5R
Sex of cell Male
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-964

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133818,23
D3S135815
D5S8189,10
D7S8209,11
D8S117914,16
D13S3178
D16S5399,11
D18S5113,15
D19S43312
D21S1130,30.2
FGA20,21
Penta D9,14
Penta E11,17
TH016,9
TPOX8,12
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Goto H., Naruto T., Tanoshima R., Kato H., Yokosuka T., Yanagimachi M., Fujii H., Yokota S., Komine H.
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-964
Encyclopedic resources Wikidata; Q54995375
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number13