ID   YCUB-5
AC   CVCL_A085
SY   YCUB5; YcuB5; Yokohama City University BCP-ALL-5
DR   DSMZ; ACC-964
DR   Wikidata; Q54995375
RX   PubMed=19157546;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: ~72 hours (DSMZ=ACC-964).
CC   Sequence variation: Gene fusion; HGNC; HGNC:14281; CRLF2 + HGNC; HGNC:15524; P2RY8; Name(s)=P2RY8-CRLF2; Note=P2RY8 exon 1 fused to CRLF2 exon 1 (PubMed=29786757).
CC   Sequence variation: Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Arg683Ile (c.2048G>T); Zygosity=Unspecified (PubMed=29786757).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=29786757).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-964
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8
ST   D16S539: 9,11
ST   D18S51: 13,15
ST   D19S433: 12
ST   D21S11: 30,30.2
ST   D2S1338: 18,23
ST   D3S1358: 15
ST   D5S818: 9,10
ST   D7S820: 9,11
ST   D8S1179: 14,16
ST   FGA: 20,21
ST   Penta D: 9,14
ST   Penta E: 11,17
ST   TH01: 6,9
ST   TPOX: 8,12
ST   vWA: 16
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A086 ! YCUB-5R
SX   Male
AG   12Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 13
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RX   PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003;
RA   Goto H., Naruto T., Tanoshima R., Kato H., Yokosuka T.,
RA   Yanagimachi M., Fujii H., Yokota S., Komine H.;
RT   "Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic
RT   leukemia cell lines, YCUB series, derived from children.";
RL   Leuk. Res. 33:1386-1391(2009).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//