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Cellosaurus OV-4453 (CVCL_9T20)

[Text version]
Cell line name OV-4453
Synonyms OV4453
Accession CVCL_9T20
Resource Identification Initiative To cite this cell line use: OV-4453 (RRID:CVCL_9T20)
Comments Doubling time: 2.44 +- 0.03 days (PubMed=26622941).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Miscellaneous: STR profile from personal communication of Mes-Masson, Anne-Marie.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Glu1953Ter (c.5857G>T); ClinVar=VCV000051952; Zygosity=Unspecified (PubMed=26622941).
  • Mutation; HGNC; HGNC:19291; CSMD3; Simple; p.Ser646Thr (c.1937G>C); Zygosity=Unspecified (PubMed=26622941).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.2490-5_2490-1del5; Zygosity=Unspecified (PubMed=26622941).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=26622941).
Disease BRCA2-associated hereditary breast and ovarian cancer syndrome (NCIt: C36101)
High grade ovarian serous adenocarcinoma (NCIt: C105555)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11
D5S8189
D7S8208,11
D13S31712
D16S53912
D21S1130,31
TH017
TPOX8
vWA14,18

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Publications

PubMed=26622941; DOI=10.18632/genesandcancer.76; PMCID=PMC4633166
Fleury H., Communal L., Carmona E., Portelance L., Arcand S.L., Rahimi K., Tonin P.N., Provencher D.M., Mes-Masson A.-M.
Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease.
Genes Cancer 6:378-398(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9T20
Encyclopedic resources Wikidata; Q54936830
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number16