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Cellosaurus KAS-6/1 (CVCL_9544)

[Text version]
Cell line name KAS-6/1
Synonyms KAS 6/1; KAS6/1; KAS-6; KAS61
Accession CVCL_9544
Resource Identification Initiative To cite this cell line use: KAS-6/1 (RRID:CVCL_9544)
Comments Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M524 ! KAS-6/2
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=8656685
Westendorf J.J., Ahmann G.J., Greipp P.R., Witzig T.E., Lust J.A., Jelinek D.F.
Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6.
Leukemia 10:866-876(1996)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1182/blood.V112.11.2732.2732
Keats J.J., Arendt B.K., Braggio E., Barrett M.T., Price-Troska T.L., Fonseca R., Bergsagel P.L., Jelinek D.F.
Comparison of multiple myeloma donor patient samples and derived cell lines identifies a confirmed hyperdiploid myeloma cell line and demonstrates remarkable genetic similarity between cell lines and patient samples.
Blood 112 Suppl. 1:2732a-2732a(2008)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=24013424; DOI=10.4161/cc.26193; PMCID=PMC3865013
Walters D.K., Arendt B.K., Jelinek D.F.
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.
Cell Cycle 12:3175-3183(2013)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B., Sirota M., Wiita A.P.
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54899506
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number16