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Cellosaurus THP-4 (CVCL_9247)

[Text version]
Cell line name THP-4
Synonyms Tohoku Hospital Pediatrics-4
Accession CVCL_9247
Resource Identification Initiative To cite this cell line use: THP-4 (RRID:CVCL_9247)
Comments Population: Japanese.
Doubling time: 52 hours (PubMed=2954268).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
Publications

PubMed=2954268; DOI=10.1620/tjem.151.283
Minegishi M., Tsuchiya S., Minegishi N., Konno T.
Establishment of five human malignant non-T lymphoid cell lines and mixed lymphocyte-tumor reaction.
Tohoku J. Exp. Med. 151:283-292(1987)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15182431; DOI=10.1111/j.1349-7006.2004.tb03240.x; PMCID=PMC11159863
Yuki Y., Imoto I., Imaizumi M., Hibi S., Kaneko Y., Amagasa T., Inazawa J.
Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).
Cancer Sci. 95:503-507(2004)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q54972353
Polymorphism and mutation databases Cosmic; 1037728
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number15