ID   THP-4
AC   CVCL_9247
SY   Tohoku Hospital Pediatrics-4
DR   Cosmic; 1037728
DR   Wikidata; Q54972353
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2954268;
RX   PubMed=8558913;
RX   PubMed=15182431;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: 52 hours (PubMed=2954268).
CC   Sequence variation: Gene fusion; HGNC; HGNC:8632; PBX1 + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-PBX1, E2A-PBX1 (PubMed=15182431).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Thr1150Ala (c.3448A>G); dbSNP=rs1726911919; Zygosity=Heterozygous (PubMed=35124168).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80347; B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1)
DI   ORDO; Orphanet_585956; B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   2Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 15
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=2954268; DOI=10.1620/tjem.151.283;
RA   Minegishi M., Tsuchiya S., Minegishi N., Konno T.;
RT   "Establishment of five human malignant non-T lymphoid cell lines and
RT   mixed lymphocyte-tumor reaction.";
RL   Tohoku J. Exp. Med. 151:283-292(1987).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=15182431; DOI=10.1111/j.1349-7006.2004.tb03240.x; PMCID=PMC11159863;
RA   Yuki Y., Imoto I., Imaizumi M., Hibi S., Kaneko Y., Amagasa T.,
RA   Inazawa J.;
RT   "Identification of a novel fusion gene in a pre-B acute lymphoblastic
RT   leukemia with t(1;19)(q23;p13).";
RL   Cancer Sci. 95:503-507(2004).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//