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Cellosaurus MM1.R (CVCL_8794)

[Text version]
Cell line name MM1.R
Synonyms MM1.r; MM.1R; MM1-R; MM-1R; MM1R; MM1.R(L); MM1.RL
Accession CVCL_8794
Resource Identification Initiative To cite this cell line use: MM1.R (RRID:CVCL_8794)
Comments Part of: MD Anderson Cell Lines Project.
Population: African American.
Characteristics: Produces IgA lambda (ATCC=CRL-2975).
Characteristics: Resistant to dexamethasone.
Doubling time: ~72 hours (ATCC=CRL-2975).
Omics: Array-based CGH.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Val536_Asn545delValPheValAlaGlnThrValLeuGluAsninsAsp (c.1604-1630delTCTTTGTGGCCCAAACTGTTCTAGAAA); Zygosity=Homozygous (PubMed=17692805).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5801 (MM.1)
Sex of cell Female
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2975; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO9,14
D1S165611,12
D2S44111
D2S133821,22
D3S135816,17
D5S8188,12
D7S82010,11
D8S117914
D10S124812,15
D12S39117,24
D13S31713
D16S53912
D18S5111,16
D19S43313
D21S1129,30
D22S104510,11
FGA20,24
Penta D2.2,9
Penta E13,15
TH017,8
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
https://tcpaportal.org/mclp/
Publications

PubMed=12691914; DOI=10.1016/S0301-472X(03)00023-7
Greenstein S., Krett N.L., Kurosawa Y., Ma C.-G., Chauhan D., Hideshima T., Anderson K.C., Rosen S.T.
Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells.
Exp. Hematol. 31:271-282(2003)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Keats J.J., Fonseca R., Chesi M., Schop R., Baker A., Chng W.-J., Van Wier S., Tiedemann R., Shi C.-X., Sebag M., Braggio E., Henry T., Zhu Y.-X., Fogle H., Price-Troska T.L., Ahmann G.J., Mancini C., Brents L.A., Kumar S.K., Greipp P.R., Dispenzieri A., Bryant B., Mulligan G., Bruhn L., Barrett M.T., Valdez R., Trent J.M., Stewart A.K., Carpten J.D., Bergsagel P.L.
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B., Sirota M., Wiita A.P.
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-2975
IZSLER; BS TCL 235
Cell line databases/resources CCRID; 3101HUMSCSP5050
Cell_Model_Passport; SIDM01264
Anatomy/cell type resources BTO; BTO:0003929
Encyclopedic resources Wikidata; Q54906036
Gene expression databases GEO; GSM1374684
Polymorphism and mutation databases Cosmic; 1424219
Cosmic; 2081429
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number22