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Cellosaurus TDL-4 (CVCL_8431)

[Text version]
Cell line name TDL-4
Accession CVCL_8431
Resource Identification Initiative To cite this cell line use: TDL-4 (RRID:CVCL_8431)
Comments Problematic cell line: Contaminated. Shown to be a Raji derivative (PubMed=6248453; PubMed=20143388). Originally thought to be a tonsillar lymphoid cell line from a female patient with recurrent exudative tonsillitis.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00100.
Population: African; Nigerian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6248453; DOI=10.1007/BF02618368
Conner B.R., Ferrone S., Pellegrino M.A., Glaser R.
Lymphoid cell line identification and the detection of cross contamination.
In Vitro 16:446-452(1980)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8431
Cell_Model_Passport; SIDM00843
Biological sample resources BioSample; SAMN03151900
Encyclopedic resources Wikidata; Q54971926
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28