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Cellosaurus HN-6 (CVCL_8129)

[Text version]
Cell line name HN-6
Synonyms HN6; LICR-LON-HN6; LICR (LON) HN6; LICR-HN-6; LICR-HN6; LICR (Lond) HN-6; LICR(Lond)-HN 6
Accession CVCL_8129
Resource Identification Initiative To cite this cell line use: HN-6 (RRID:CVCL_8129)
Comments Doubling time: 32 hours (PubMed=7195729).
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_EJ03 ! HN-6n1
CVCL_A1TI ! HN-6n2
CVCL_A1TJ ! HN-6Rr
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719
Easty D.M., Easty G.C., Carter R.L., Monaghan P., Butler L.J.
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Br. J. Cancer 43:772-785(1981)

PubMed=7284233; DOI=10.1038/bjc.1981.193; PMCID=PMC2010768
Easty D.M., Easty G.C., Carter R.L., Monaghan P., Pittam M.R., James T.
Five human tumour cell lines derived from a primary squamous carcinoma of the tongue, two subsequent local recurrences and two nodal metastases.
Br. J. Cancer 44:363-370(1981)

PubMed=6387708; DOI=10.1073/pnas.81.21.6632; PMCID=PMC391984
Pfyffer G.E., Haemmerli G., Heizmann C.W.
Calcium-binding proteins in human carcinoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 81:6632-6636(1984)

PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6
Easty D.M., Easty G.C., Baici A., Carter R.L., Cederholm-Williams S.A., Felix H., Gusterson B.A., Haemmerli G., Hauser-Urfer I.H., Heizmann C.W., Mareel M.M., Stehrenberger B., Strauli P.
Biological studies of ten human squamous carcinoma cell lines: an overview.
Eur. J. Cancer Clin. Oncol. 22:617-634(1986)

PubMed=2183872; DOI=10.1038/bjc.1990.80; PMCID=PMC1971288
Rumsby G., Carter R.L., Gusterson B.A.
Low incidence of ras oncogene activation in human squamous cell carcinomas.
Br. J. Cancer 61:365-368(1990)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I
O-Charoenrat P., Rhys-Evans P.H., Modjtahedi H., Court W., Box G., Eccles S.A.
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.
Int. J. Cancer 86:307-317(2000)

PubMed=12124801; DOI=10.1002/ijc.10531
O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
Int. J. Cancer 100:527-533(2002)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4879547
Encyclopedic resources Wikidata; Q54889994
Polymorphism and mutation databases Cosmic; 706633
Cosmic; 916366
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number19