ID   HN-6
AC   CVCL_8129
SY   HN6; LICR-LON-HN6; LICR (LON) HN6; LICR-HN-6; LICR-HN6; LICR (Lond) HN-6; LICR(Lond)-HN 6
DR   ChEMBL-Cells; CHEMBL4879547
DR   Cosmic; 706633
DR   Cosmic; 916366
DR   Wikidata; Q54889994
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=2183872;
RX   PubMed=2427339;
RX   PubMed=6387708;
RX   PubMed=7195729;
RX   PubMed=7284233;
RX   PubMed=10760816;
RX   PubMed=12124801;
CC   Doubling time: 32 hours (PubMed=7195729).
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_EJ03 ! HN-6n1
OI   CVCL_A1TI ! HN-6n2
OI   CVCL_A1TJ ! HN-6Rr
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 19
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=2183872; DOI=10.1038/bjc.1990.80; PMCID=PMC1971288;
RA   Rumsby G., Carter R.L., Gusterson B.A.;
RT   "Low incidence of ras oncogene activation in human squamous cell
RT   carcinomas.";
RL   Br. J. Cancer 61:365-368(1990).
//
RX   PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6;
RA   Easty D.M., Easty G.C., Baici A., Carter R.L.,
RA   Cederholm-Williams S.A., Felix H., Gusterson B.A., Haemmerli G.,
RA   Hauser-Urfer I.H., Heizmann C.W., Mareel M.M., Stehrenberger B.,
RA   Strauli P.;
RT   "Biological studies of ten human squamous carcinoma cell lines: an
RT   overview.";
RL   Eur. J. Cancer Clin. Oncol. 22:617-634(1986).
//
RX   PubMed=6387708; DOI=10.1073/pnas.81.21.6632; PMCID=PMC391984;
RA   Pfyffer G.E., Haemmerli G., Heizmann C.W.;
RT   "Calcium-binding proteins in human carcinoma cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6632-6636(1984).
//
RX   PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719;
RA   Easty D.M., Easty G.C., Carter R.L., Monaghan P., Butler L.J.;
RT   "Ten human carcinoma cell lines derived from squamous carcinomas of
RT   the head and neck.";
RL   Br. J. Cancer 43:772-785(1981).
//
RX   PubMed=7284233; DOI=10.1038/bjc.1981.193; PMCID=PMC2010768;
RA   Easty D.M., Easty G.C., Carter R.L., Monaghan P., Pittam M.R.,
RA   James T.;
RT   "Five human tumour cell lines derived from a primary squamous
RT   carcinoma of the tongue, two subsequent local recurrences and two
RT   nodal metastases.";
RL   Br. J. Cancer 44:363-370(1981).
//
RX   PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I;
RA   O-Charoenrat P., Rhys-Evans P.H., Modjtahedi H., Court W., Box G.,
RA   Eccles S.A.;
RT   "Overexpression of epidermal growth factor receptor in human head and
RT   neck squamous carcinoma cell lines correlates with matrix
RT   metalloproteinase-9 expression and in vitro invasion.";
RL   Int. J. Cancer 86:307-317(2000).
//
RX   PubMed=12124801; DOI=10.1002/ijc.10531;
RA   O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.;
RT   "A synthetic matrix metalloproteinase inhibitor prevents squamous
RT   carcinoma cell proliferation by interfering with epidermal growth
RT   factor receptor autocrine loops.";
RL   Int. J. Cancer 100:527-533(2002).
//