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Cellosaurus HN-5 (CVCL_8128)

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Cell line name HN-5
Synonyms HN5; LICR-LON-HN5; LICR (LON) HN5; LICR-HN5; LICR-HN-5; LICR HN-5
Accession CVCL_8128
Resource Identification Initiative To cite this cell line use: HN-5 (RRID:CVCL_8128)
Comments Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: 34 hours (PubMed=7195729).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: HNS; Cosmic=1530740.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LI55 (LICR-HN5 R9.1)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=17254797; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11 (PubMed=17254797)
11,13 (PubMed=21868764)
D3S135818
D5S81813
D7S82011
D8S117911,12
D13S31711
D16S53910,12 (PubMed=17254797)
11,13 (PubMed=21868764)
D18S5112,14
D21S1127,31
FGA24
TH019
TPOX8,11
vWA15,18,19

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719
Easty D.M., Easty G.C., Carter R.L., Monaghan P., Butler L.J.
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Br. J. Cancer 43:772-785(1981)

PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6
Easty D.M., Easty G.C., Baici A., Carter R.L., Cederholm-Williams S.A., Felix H., Gusterson B., Haemmerli G., Hauser-Urfer I.H., Heizmann C.W., Mareel M.M., Stehrenberger B., Strauli P.
Biological studies of ten human squamous carcinoma cell lines: an overview.
Eur. J. Cancer Clin. Oncol. 22:617-634(1986)

PubMed=2183872; DOI=10.1038/bjc.1990.80; PMCID=PMC1971288
Rumsby G., Carter R.L., Gusterson B.A.
Low incidence of ras oncogene activation in human squamous cell carcinomas.
Br. J. Cancer 61:365-368(1990)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I
O-Charoenrat P., Rhys-Evans P.H., Modjtahedi H., Court W., Box G., Eccles S.A.
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.
Int. J. Cancer 86:307-317(2000)

PubMed=12124801; DOI=10.1002/ijc.10531
O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
Int. J. Cancer 100:527-533(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Jeddi-Tehrani M., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624
Boeckx C., Van den Bossche J., De Pauw I., Peeters M., Lardon F., Baay M., Wouters A.
The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.
BMC Res. Notes 8:203.1-203.6(2015)

PubMed=26269754; PMCID=PMC4529614
Boeckx C., Blockx L., Op de Beeck K., Limame R., Van Camp G., Peeters M., Vermorken J.B., Specenier P., Wouters A., Baay M., Lardon F.
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.
Am. J. Cancer Res. 5:1921-1938(2015)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections (Providers) NCBI_Iran; C196
Chemistry resources ChEMBL-Cells; CHEMBL3308481
ChEMBL-Targets; CHEMBL614828
PubChem_Cell_line; CVCL_8128
Encyclopedic resources Wikidata; Q54889993
Experimental variables resources EFO; EFO_0022405
Gene expression databases GEO; GSM1374540
GEO; GSM1374541
Polymorphism and mutation databases Cosmic; 686977
Cosmic; 706622
Cosmic; 916365
Cosmic; 1339911
Cosmic; 1530740
Cosmic; 2131847
Cosmic; 2439753
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number28