ID   HN-5
AC   CVCL_8128
SY   HN5; LICR-LON-HN5; LICR (LON) HN5; LICR-HN5; LICR-HN-5; LICR HN-5
DR   ChEMBL-Cells; CHEMBL3308481
DR   ChEMBL-Targets; CHEMBL614828
DR   Cosmic; 686977
DR   Cosmic; 706622
DR   Cosmic; 916365
DR   Cosmic; 1339911
DR   Cosmic; 1530740
DR   Cosmic; 2131847
DR   Cosmic; 2439753
DR   GEO; GSM1374540
DR   GEO; GSM1374541
DR   NCBI_Iran; C196
DR   PubChem_Cell_line; CVCL_8128
DR   Wikidata; Q54889993
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=2183872;
RX   PubMed=2427339;
RX   PubMed=7195729;
RX   PubMed=10760816;
RX   PubMed=12124801;
RX   PubMed=17254797;
RX   PubMed=21868764;
RX   PubMed=26032726;
RX   PubMed=26269754;
RX   PubMed=26754630;
RX   PubMed=28196595;
RX   PubMed=29156801;
WW   https://tcpaportal.org/mclp/
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Doubling time: 34 hours (PubMed=7195729).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: HNS; Cosmic=1530740.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=17254797; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 10,11 (PubMed=17254797)
ST   CSF1PO: 11,13 (PubMed=21868764)
ST   D13S317: 11
ST   D16S539: 10,12 (PubMed=17254797)
ST   D16S539: 11,13 (PubMed=21868764)
ST   D18S51: 12,14
ST   D21S11: 27,31
ST   D3S1358: 18
ST   D5S818: 13
ST   D7S820: 11
ST   D8S1179: 11,12
ST   FGA: 24
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 15,18,19
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   73Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 27
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=2183872; DOI=10.1038/bjc.1990.80;
RA   Rumsby G., Carter R.L., Gusterson B.A.;
RT   "Low incidence of ras oncogene activation in human squamous cell
RT   carcinomas.";
RL   Br. J. Cancer 61:365-368(1990).
//
RX   PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6;
RA   Easty D.M., Easty G.C., Baici A., Carter R.L.,
RA   Cederholm-Williams S.A., Felix H., Gusterson B., Haemmerli G.,
RA   Hauser-Urfer I.H., Heizmann C.W., Mareel M.M., Stehrenberger B.,
RA   Strauli P.;
RT   "Biological studies of ten human squamous carcinoma cell lines: an
RT   overview.";
RL   Eur. J. Cancer Clin. Oncol. 22:617-634(1986).
//
RX   PubMed=7195729; DOI=10.1038/bjc.1981.115;
RA   Easty D.M., Easty G.C., Carter R.L., Monaghan P., Butler L.J.;
RT   "Ten human carcinoma cell lines derived from squamous carcinomas of
RT   the head and neck.";
RL   Br. J. Cancer 43:772-785(1981).
//
RX   PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I;
RA   O-Charoenrat P., Rhys-Evans P.H., Modjtahedi H., Court W., Box G.,
RA   Eccles S.A.;
RT   "Overexpression of epidermal growth factor receptor in human head and
RT   neck squamous carcinoma cell lines correlates with matrix
RT   metalloproteinase-9 expression and in vitro invasion.";
RL   Int. J. Cancer 86:307-317(2000).
//
RX   PubMed=12124801; DOI=10.1002/ijc.10531;
RA   O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.;
RT   "A synthetic matrix metalloproteinase inhibitor prevents squamous
RT   carcinoma cell proliferation by interfering with epidermal growth
RT   factor receptor autocrine loops.";
RL   Int. J. Cancer 100:527-533(2002).
//
RX   PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001;
RA   Azari S., Ahmadi N., Jeddi-Tehrani M., Shokri F.;
RT   "Profiling and authentication of human cell lines using short tandem
RT   repeat (STR) loci: report from the National Cell Bank of Iran.";
RL   Biologicals 35:195-202(2007).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=26032726; DOI=10.1186/s13104-015-1197-6;
RA   Boeckx C., Van den Bossche J., De Pauw I., Peeters M., Lardon F.,
RA   Baay M., Wouters A.;
RT   "The hypoxic tumor microenvironment and drug resistance against EGFR
RT   inhibitors: preclinical study in cetuximab-sensitive head and neck
RT   squamous cell carcinoma cell lines.";
RL   BMC Res. Notes 8:203.1-203.6(2015).
//
RX   PubMed=26269754;
RA   Boeckx C., Blockx L., Op de Beeck K., Limame R., Van Camp G.,
RA   Peeters M., Vermorken J.B., Specenier P., Wouters A., Baay M.,
RA   Lardon F.;
RT   "Establishment and characterization of cetuximab resistant head and
RT   neck squamous cell carcinoma cell lines: focus on the contribution of
RT   the AP-1 transcription factor.";
RL   Am. J. Cancer Res. 5:1921-1938(2015).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4;
RA   Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S.,
RA   Ito Y., Myers J.N., Oridate N.;
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//